《Enhanced efficacy of gefitinib in drug-sensitive and drug-resistant cancer cell lines after arming with a singlet oxygen releasing moiety》 was written by Huang, Kunshan; Huo, Beibei; Li, Dongyao; Xue, Jinping; Chen, Juanjuan. Reference of 1,4-Bis(bromomethyl)benzene And the article was included in ChemMedChem in 2020. The article conveys some information:
Attractive results have been achieved with small-mol. target-based drugs in the anticancer field; however, enhancing their treatment effect and solving the problem of drug resistance remain key concerns worldwide. Inspired by the specific affinity of gefitinib for tumor cells and the strong oxidation capacity of singlet oxygen, we combined a chem. generated singlet oxygen moiety with the small-mol. targeted drug gefitinib to improve its anticancer effect. We designed and synthesized a novel compound (Y5-1), in which a small-mol. targeted therapy agent (gefitinib) and a singlet oxygen (provided by an in vitro photodynamic reaction) thermally controlled releasing moiety are covalently conjugated. We demonstrated that the introduction of the singlet oxygen thermally controlled releasing moiety enhanced the anticancer activities of gefitinib. The results of this study are expected to provide a novel strategy to enhance the effect of chemotherapy drugs on drug-resistant cell lines. In the part of experimental materials, we found many familiar compounds, such as 1,4-Bis(bromomethyl)benzene(cas: 623-24-5Reference of 1,4-Bis(bromomethyl)benzene)
1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Reference of 1,4-Bis(bromomethyl)benzene In contrast, terrestrial plants account only for a few bromine-containing compounds.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary