In 2022,Hu, Liqun; Liu, Yibing; Fang, Xiong; zheng, Yuzhu; Liao, Rong-zhen; Li, Man; Xie, Youwei published an article in ACS Catalysis. The title of the article was 《An Intermolecular Hydroarylation of Highly Deactivated Styrenes Catalyzed by Re2O7/HReO4 in Hexafluoroisopropanol》.Safety of Ethyltriphenylphosphonium bromide The author mentioned the following in the article:
Here, authors describe an activation mode for unactivated alkenes on the basis of a synergy between Re2O7/HReO4 and hexafluoroisopropanol (HFIP). Highly electron-deficient styrenes have been activated to effect a challenging intermol. hydroarylation with different arenes to give a variety of diarylalkanes in high efficiency. This method is characterized by mild reaction condition, broad substrate scope, high chem. yields, and minimal waste generation. The potential synthetic application of this methodol. was exemplified by the efficient synthesis of a retinoic acid receptor (RAR) agonist. DFT calculations and deuterium-labeling experiments were conducted to elucidate the reaction mechanism, and both confirmed the critical role of HFIP, which significantly reduced the energetical barriers for several key steps of this transformation via a network of hydrogen bonding to perrhenate anion with two equivalent of HFIP. In addition to this study using Ethyltriphenylphosphonium bromide, there are many other studies that have used Ethyltriphenylphosphonium bromide(cas: 1530-32-1Safety of Ethyltriphenylphosphonium bromide) was used in this study.
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. It is also used as catalysts in the synthesis of certain organic compounds and as a pharmaceutical intermediate.Safety of Ethyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary