《Enolizable Ketones as Activators of Palladium(II) Precatalysts in Amine Arylation Reactions》 was published in ACS Catalysis in 2020. These research results belong to Hu, Huaiyuan; Gilliam, Ashley M.; Qu, Fengrui; Shaughnessy, Kevin H.. Name: 1-Bromo-2-isopropylbenzene The article mentions the following:
Enolizable ketones were identified as effective activators for palladium(II) precatalysts in the coupling of aryl bromides and aniline. N-arylation reactions catalyzed by [(DTBNpP)PdCl2]2 (DTBNpP = (bis(tert-butyl)neopentylphosphine)) and PEPPSI-IPr precatalysts were activated by the addition of acetone, mesityl oxide and 3-pentanone, the most effective activator. Mechanistic studies showed that acetone, 3-pentanone and mesityl oxide reduce [(DTBNpP)PdCl2]2 in the presence of NaO-tert-Bu to Pd0(DTBNpP)2. In the experiment, the researchers used 1-Bromo-2-isopropylbenzene(cas: 7073-94-1Name: 1-Bromo-2-isopropylbenzene)
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 1-Bromo-2-isopropylbenzene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary