Recommanded Product: Methyl 3-(bromomethyl)benzoateIn 2016 ,《Design, synthesis and biological evaluation of stilbene derivatives as novel inhibitors of protein Tyrosine Phosphatase 1B》 was published in Molecules. The article was written by He, Haibing; Ge, Yinghua; Dai, Hong; Cui, Song; Ye, Fei; Jin, Jia; Shi, Yujun. The article contains the following contents:
By imitating the scaffold of lithocholic acid (LCA), a natural steroidal compound displaying Protein Tyrosine Phosphatase 1B (PTP1B) inhibitory activity, a series of stilbene derivatives containing phenyl-substituted isoxazoles were designed and synthesized. The structures of the title compounds were confirmed by 1H-NMR, 13C-NMR and HRMS. Activities of the title compounds were evaluated on PTP1B and the homologous enzyme TCPTP by using a colorimetric assay. Most of the target compounds had good activities against PTP1B. Among them, compound 29 (IC50 = 0.91 ± 0.33 μM), characterized by a 5-(2,3-dichlorophenyl) isoxazole moiety, exhibited an activity about 14-fold higher than the lead compound LCA and a 4.2-fold selectivity over TCPTP. Compound 29 was identified as a competitive inhibitor of PTP1B with a Ki value of 0.78 μM in enzyme kinetic studies. In the experiment, the researchers used Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Recommanded Product: Methyl 3-(bromomethyl)benzoate The most pervasive is the naturally produced bromomethane.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary