Category: bromides-buliding-blocksIn 2019 ,《Small antibacterial molecules highly active against drug-resistant Staphylococcus aureus》 was published in MedChemComm. The article was written by Dey, Rajib; De, Kathakali; Mukherjee, Riya; Ghosh, Sreyan; Haldar, Jayanta. The article contains the following contents:
The rapid growth of antibiotic resistance in Staphylococcus aureus coupled with their biofilm forming ability has made the infections difficult to treat with conventional antibiotics. This has created a massive threat towards public health and is a huge concern worldwide. Aiming to address this challenging issue, herein we report a new class of small antibacterial mols. (SAMs) with high antibacterial activity against multidrug-resistant S. aureus. The design principle of the mols. was based on the variation of hydrophobic/hydrophilic balance through incorporation of two quaternary ammonium groups, ethanol moieties, non-peptidic amide bonds and aliphatic chains. The lead compound, identified through a comprehensive anal. of structure-activity relationships, displayed high activity against clin. isolates of methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) with MIC values in the range of 1-4μg mL-1. More importantly, this compound was capable of killing stationary phase bacteria and disrupting established biofilms of MRSA. Addnl., the compound revealed min. toxicity towards human erythrocytes (HC50 = 577μg mL-1) and did not show significant toxicity towards mammalian cells (MDCK and A549) up to 128 g mL-1. Remarkably, the incorporation of non-peptidic amide bonds made the compounds less susceptible to degradation in human plasma, serum and mouse liver homogenate. Taken together, the results therefore indicate great promise for this class of mols. to be developed as potent antibacterial agents in treating infections caused by drug-resistant S. aureus. In the experiment, the researchers used many compounds, for example, 1,6-Dibromohexane(cas: 629-03-8Category: bromides-buliding-blocks)
1,6-Dibromohexane(cas: 629-03-8) is generally used to introduce C6 spacer in the molecular architecture. Some of the examples are: synthesis of pyrrolo-tetrathiafulvalene molecular bridge (6PTTF6) to study redox switching behavior of single molecules; synthesis of water-soluble thermoresponsive polylactides.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary