Electric Literature of C9H9BrO2In 2021 ,《Green Catalyst- and Additive-Free Three-Component Deamination Cyclization Synthesis of 3-Substituted-4- oxo-2-quinazolinonyl Sulfides》 appeared in ChemistrySelect. The author of the article were Zheng, Lvyin; Xie, Zhen; Cai, Liuhuan; Liu, Gongping; Mei, Weijie; Zou, Xiaoying; Zhuo, Xiaoya; Fan, Xiaolin; Guo, Wei. The article conveys some information:
An efficient three-component deamination annulation of 2-aminobenzamides 2-NH2-RC6H4C(O)NH2 (R = H, 3-Me, 4-F, 5-Cl, etc.), isothiocyanates R1NCS (R1 = Ph, Bn, Me, etc.) and alkyl bromides R2R3CHBr (R2 = ethoxycarbonyl, benzyloxycarbonyl, Ph, etc.; R3 = H, Et, Pr, Bu, phenyl) for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides I (R4 = H, 6-Me, 7-Cl, 8-Br, etc.) is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides I as potential anti-cancer agents in medicinal chem. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Electric Literature of C9H9BrO2)
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Electric Literature of C9H9BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary