In 2022,Yu, Mingming; Gao, Yuhan; Zhang, Lin; Zhang, Yingjie; Zhang, Yiyan; Yi, Hong; Huang, Zhiliang; Lei, Aiwen published an article in Green Chemistry. The title of the article was 《Electrochemical-induced benzyl C-H amination towards the synthesis of isoindolinones via aroyloxy radical-mediated C-H activation》.Category: bromides-buliding-blocks The author mentioned the following in the article:
A novel electrochem. strategy to selectively and sustainably access isoindolinones I [R1 = H, 7-Me, 5-F, etc.; R2 = H, Me, Et, n-Pr, i-Pr, n-Bu; R3 = Me, n-Pr, i-Pr, n-Bu, cyclopropyl, CD3] using simple o-alkyl benzoic acids and nitriles as substrates under metal catalyst and external oxidant-free conditions was developed. Meanwhile, nitrile as the nitrogen source plays a vital role, as its derived intermediate facilitates the construction of the amide bond in the product. Mechanistic investigations suggest that aroyloxy radicals were involved in this transformation, which initiated the benzylic C-H amination event by a 1,5-HAT process. The protocol showed a very good functional group tolerance.3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks) was used in this study.
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary