Application In Synthesis of Methyl 3-(bromomethyl)benzoateIn 2022 ,《Cobalt-Catalyzed 1,1,3-Triborylation of Terminal Alkynes》 was published in Organometallics. The article was written by Yang, Xiaoxu; Ge, Shaozhong. The article contains the following contents:
The authors have developed a Co-catalyzed regioselective 1,1,3-triborylation reaction of terminal alkynes with pinacolborane (HBpin) with a catalyst generated in situ from readily available and bench-stable Co(acac)2 and xantphos. A variety of terminal alkynes undergo this triborylation reaction, affording the corresponding 1,1,3-triborylalkanes in good yields with high selectivity. The synthetic utility of this catalytic protocol was demonstrated by developing selective stepwise functionalization of 1,1,3-triborylalkane products. The results of mechanistic studies, such as conducting control experiments and D-labeling reactions, monitoring the reaction process, and identifying reaction intermediates, suggest that this 1,1,3-triborylation reaction proceeds through 1,3-diborylation of alken-1-ylboronates formed by Co-catalyzed hydroboration of terminal alkynes. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Application In Synthesis of Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. In contrast, terrestrial plants account only for a few bromine-containing compounds.Application In Synthesis of Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary