Yamazaki, Ken; Gabriel, Pablo; Di Carmine, Graziano; Pedroni, Julia; Farizyan, Mirxan; Hamlin, Trevor A.; Dixon, Darren J. published an article in 2021. The article was titled 《General Pyrrolidine Synthesis via Iridium-Catalyzed Reductive Azomethine Ylide Generation from Tertiary Amides and Lactams》, and you may find the article in ACS Catalysis.Recommanded Product: 5437-45-6 The information in the text is summarized as follows:
An iridium-catalyzed reductive generation of both stabilized and unstabilized azomethine ylides and their application to functionalized pyrrolidines, e.g., I synthesis via [3+2] dipolar cycloaddition reactions was described. Proceeded under mild reaction conditions from both amide and lactam precursors, possessed a suitably positioned electron-withdrawing or a trimethylsilyl group, using catalytic Vaska’s complex [IrCl(CO)(PPh3)2] and tetramethyldisiloxane (TMDS) as a terminal reductant, a broad range of (un)stabilized azomethine ylides were accessible. Subsequent regio- and diastereoselective, inter- and intramol., and dipolar cycloaddition reactions with variously substituted electron-deficient alkenes enabled ready and efficient access to structurally complex pyrrolidine architectures. D. functional theory (DFT) calculations of the dipolar cycloaddition reactions uncovered an intimate balance between asynchronicity and interaction energies of transition structures, which ultimately control the unusual selectivities observed in certain cases. In the part of experimental materials, we found many familiar compounds, such as Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary