In 2022,Wang, Yingcheng; Zhou, Xue; Shan, Wenyu; Liao, Ruisong; Deng, YuHua; Peng, Fangzhi; Shao, Zhihui published an article in ACS Catalysis. The title of the article was 《Construction of Axially Chiral Indoles by Cycloaddition-Isomerization via Atroposelective Phosphoric Acid and Silver Sequential Catalysis》.Category: bromides-buliding-blocks The author mentioned the following in the article:
Herein, the atroposelective organo/metal combined dual catalysis strategy for de novo construction of valuable axially chiral indole frameworks I [R = n-Bu, Ph, 2-naphthyl, etc.; R1 = H, 6-Br, 7-C6H5, etc.; R2 = i-Pr, t-Bu, cyclohexyl; R3 = Boc, Cbz] was developed. This protocol utilized a catalyst system of two chiral phosphoric acids (1 mol %) in combination with AgNO3 (1 mol %) and was based on the unreported intermol. cycloaddition-isomerization reaction of recently introduced C-alkynyl N,O-acetals and 2-naphthylamines. An important class of hitherto inaccessible axially chiral indoles with a C-N axis were obtained in good yields and enantioselectivities. The axially chiral indoles obtained also provided a platform for the catalyst-controlled atroposelective synthesis of axially chiral indoles bearing two C-N axes, which were difficult to access by the existing methods. This work was also an example of 2-naphthylamines used as 1,3-dinucleophiles and three-atom (CCN) synthons in cycloadditions1-Bromo-2-isopropylbenzene(cas: 7073-94-1Category: bromides-buliding-blocks) was used in this study.
1-Bromo-2-isopropylbenzene(cas: 7073-94-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary