In 2022,Wang, Hongyu; Liu, Chen-Fei; Martin, Robert T.; Gutierrez, Osvaldo; Koh, Ming Joo published an article in Nature Chemistry. The title of the article was 《Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes》.COA of Formula: C4H7Br The author mentioned the following in the article:
A directing-group-free, nickel-catalyzed strategy that couples a broad array of unactivated and activated olefins, e.g., (3-methylbut-3-en-1-yl)benzene with aryl-substituted triflates, e.g., p-tolyl trifluoromethanesulfonate and organometallic nucleophiles, e.g., phenylmagnesium bromide to afford diarylation adducts, e.g., (2-methyl-2-(p-tolyl)butane-1,4-diyl)dibenzene in either regioisomeric form, in up to 93% yield and >98% site selectivity was described. By switching the reagents involved, the present strategy may be extended to other classes of dicarbofunctionalization reactions. Mechanistic and computational investigations offer insights into the origin of the observed regiochem. outcome and the utility of the method is highlighted through the concise syntheses of biol. active mols. The catalyst control principles reported are expected to advance efforts towards the development of general site-selective alkene functionalization, removing the requirement for neighboring activating groups. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5COA of Formula: C4H7Br)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.COA of Formula: C4H7Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary