In 2012,Ueno, Satoshi; Komiya, Sadakazu; Tanaka, Takeshi; Kuwano, Ryoichi published 《Intramolecular SN’-Type Aromatic Substitution of Benzylic Carbonates at their Para-Position》.Organic Letters published the findings.Category: bromides-buliding-blocks The information in the text is summarized as follows:
The benzylic carbonates, which connect with an active methine through an o-phenylene tether at their meta-position, are cyclized by Pd(η3-C3H5)Cp-S-Phos catalyst, yielding 3-methyl-9,10-dihydrophenanthrenes, e.g., I. In the catalytic cyclization, the internal nucleophile attacks not the ortho-carbon but the para-carbon of the benzylic ester. The [3 + 2] cycloaddition of m-(silylmethyl)benzyl carbonates with alkylidene malonates was developed from the palladium-catalyzed intramol. SN’-type aromatic substitution. The experimental process involved the reaction of 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Category: bromides-buliding-blocks)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary