Formula: C18H12Br3NIn 2021 ,《Facile antibacterial materials with turbine-like structure for P. aeruginosa infected scald wound healing》 appeared in Biomaterials Science. The author of the article were Tao, Qin; Guo, Lixia; Diao, Haipeng; Feng, Liheng. The article conveys some information:
Pseudomonas aeruginosa (P. aeruginosa) is a popular hospital pathogen and the major cause of morbidity and mortality in patients with cystic fibrosis (CF) and impaired immune system. Herein, we designed and synthesized a series of organic mols. MTEBT-n (n = 1, 2, 3) to specifically and effectively kill P. aeruginosa. Hydrophobic triphenylamine was selected as the skeleton, and hydrophilic primary ammonium salts that can easily penetrate the cell walls of Gram-neg. bacteria and accumulate in the bacteria were used to adjust the hydrophilic-hydrophobic ratio of the mols., resulting in different antibacterial activity. As the hydrophilic-hydrophobic ratio increased in the structures from MTEBT-1 to MTEBT-3, the antibacterial activity of the three mols. were gradually enhanced with killing effects of 25%, 75% and 95% against P. aeruginosa, resp. The antibacterial mechanisms of MTEBT-n were demonstrated to destroy the bacterial membrane, which could effectively prevent the development of drug resistance. In addition, MTEBT-3 with the highest antibacterial activity could inhibit P. aeruginosa biofilm very well, and heal the P. aeruginosa infected scald wounds. This work provides a potential organic antimicrobial material for clin. antimicrobial therapy of P. aeruginosa infection, and offers a mol. engineering strategy for designing new antimicrobials. In addition to this study using Tris(4-bromophenyl)amine, there are many other studies that have used Tris(4-bromophenyl)amine(cas: 4316-58-9Formula: C18H12Br3N) was used in this study.
In general, Tris(4-bromophenyl)amine(cas: 4316-58-9) is often used in the synthesis of porous luminescent covalent–organic polymers (COPs)Formula: C18H12Br3N
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary