Recommanded Product: 4-Bromobenzoic acidIn 2020 ,《A practical catalytic reductive amination of carboxylic acids》 was published in Chemical Science. The article was written by Stoll, Emma L.; Tongue, Thomas; Andrews, Keith G.; Valette, Damien; Hirst, David J.; Denton, Ross M.. The article contains the following contents:
Reductive alkylation reactions of amines using carboxylic acids as nominal electrophiles was reported. The two-step reaction exploits the dual reactivity of phenylsilane and involves a silane-mediated amidation followed by a Zn(OAc)2-catalyzed amide reduction The reaction is applicable to a wide range of amines and carboxylic acids and has been demonstrated on a large scale (305 mmol of amine). The rate differential between the reduction of tertiary and secondary amide intermediates is exemplified in a convergent synthesis of the antiretroviral medicine maraviroc. Mechanistic studies demonstrate that a residual 0.5 equiv of carboxylic acid from the amidation step is responsible for the generation of silane reductants with augmented reactivity, which allow secondary amides, previously unreactive in zinc/phenylsilane systems, to be reduced. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 4-Bromobenzoic acid)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 4-Bromobenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary