In 2022,Shan, Chao; Xu, Jinping; Cao, Liming; Liang, Chaoming; Cheng, Ruihua; Yao, Xiantong; Sun, Maolin; Ye, Jinxing published an article in Organic Letters. The title of the article was 《Rapid Synthesis of α-Chiral Piperidines via a Highly Diastereoselective Continuous Flow Protocol》.Electric Literature of C7H13BrO2 The author mentioned the following in the article:
A practical continuous flow protocol has been developed using readily accessible N-(tert-butylsulfinyl)-bromoimine and Grignard reagents, providing various functionalized piperidines (34 examples) in superior results (typically >80% yield and with >90:10 dr) within minutes. The high-performance scale-up is smoothly carried out, and efficient synthesis of the drug precursor further showcases its utility. This flow process offers rapid and scalable access to enantioenriched α-substituted piperidines. In addition to this study using Ethyl 5-bromovalerate, there are many other studies that have used Ethyl 5-bromovalerate(cas: 14660-52-7Electric Literature of C7H13BrO2) was used in this study.
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Electric Literature of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary