《Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast》 was written by Schierle, Simone; Helmstaedter, Moritz; Schmidt, Jurema; Hartmann, Markus; Horz, Maximiliane; Kaiser, Astrid; Weizel, Lilia; Heitel, Pascal; Proschak, Anna; Hernandez-Olmos, Victor; Proschak, Ewgenij; Merk, Daniel. Quality Control of Methyl 3-(bromomethyl)benzoateThis research focused onZafirlukast derivative preparation farnesoid receptor epoxide hydrolase modulator steatohepatitis; NAFLD; NASH; Polypharmacology; non-alcoholic steatohepatitis; nuclear receptor. The article conveys some information:
The nuclear farnesoid X receptor (FXR) and the enzyme soluble epoxide hydrolase (sEH) are validated mol. targets to treat metabolic disorders such as non-alc. steatohepatitis (NASH). Their simultaneous modulation in vivo has demonstrated a triad of anti-NASH effects and thus may generate synergistic efficacy. Here we report dual FXR activators/sEH inhibitors derived from the anti-asthma drug Zafirlukast. Systematic structural optimization of the scaffold has produced favorable dual potency on FXR and sEH while depleting the original cysteinyl leukotriene receptor antagonism of the lead drug. The resulting polypharmacol. activity profile holds promise in the treatment of liver-related metabolic diseases. In the experimental materials used by the author, we found Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Quality Control of Methyl 3-(bromomethyl)benzoate)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Organobromine chemicals are produced naturally by an array of biological and other chemical processes in our environment. Organobromine compounds are produced naturally by marine creatures (sponges, corals, sea slugs, tunicates, sea fans) and seaweed, plants, fungi, lichen, algae, bacteria, microbes, and some mammals. Quality Control of Methyl 3-(bromomethyl)benzoate
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