In 2018,Novikova, Daria S.; Grigoreva, Tatyana A.; Zolotarev, Andrey A.; Garabadzhiu, Alexander V.; Tribulovich, Vyacheslav G. published 《Advanced palladium free approach to the synthesis of substituted alkene oxindoles via aluminum-promoted Knoevenagel reaction》.RSC Advances published the findings.Recommanded Product: Methyl 3-(bromomethyl)benzoate The information in the text is summarized as follows:
A synthetic route for the synthesis of (E)-3-((3-((4-Chlorophenyl)(phenyl)methylene)-2-oxoindolin-1-yl)methyl)benzoic acid (I), as well as for the design of focused libraries of direct AMP-activated protein kinase (AMPK) activators was developed based on a convergent strategy. The proposed scheme corresponded to the current trends in C-H bond functionalization. The use of aluminum isopropoxide as catalyst for synthesis of substituted indolinones II [R1 = H, 4-Cl, 4-OMe, etc.; R2 = H, Me, Ph, etc.; stereo = E, Z] via Knoevenagel condensation of oxindole with benzophenones was a noticeable point of this work.Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Recommanded Product: Methyl 3-(bromomethyl)benzoate) was used in this study.
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Recommanded Product: Methyl 3-(bromomethyl)benzoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary