《Structure-Function Studies on IMD-0354 Identifies Highly Active Colistin Adjuvants》 was written by Nemeth, Ansley M.; Basak, Akash K.; Weig, Alexander W.; Marrujo, Santiana A.; Barker, William T.; Jania, Leigh A.; Hendricks, Tyler A.; Sullivan, Ashley E.; O’Connor, Patrick M.; Melander, Roberta J.; Koller, Beverly H.; Melander, Christian. Quality Control of 3,5-Dibromoaniline And the article was included in ChemMedChem in 2020. The article conveys some information:
Infections caused by multidrug-resistant (MDR) bacteria, particularly Gram-neg. bacteria, are an escalating global health threat. Often clinicians are forced to administer the last-resort antibiotic colistin; however, colistin resistance is becoming increasingly prevalent, giving rise to the potential for a situation in which there are no treatment options for MDR Gram-neg. infections. The development of adjuvants that circumvent bacterial resistance mechanisms is a promising orthogonal approach to the development of new antibiotics. We recently disclosed that the known IKK-β inhibitor IMD-0354 potently suppresses colistin resistance in several Gram-neg. strains. In this study, we explore the structure-activity relationship (SAR) between the IMD-0354 scaffold and colistin resistance suppression, and identify several compounds with more potent activity than the parent against highly colistin-resistant strains of Acinetobacter baumannii and Klebsiella pneumoniae. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Quality Control of 3,5-Dibromoaniline)
3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of 3,5-Dibromoaniline
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary