《Selectively Oxidative C(sp2)-H/C(sp3)-H Cross-Coupling of Benzamides with Amides by Nickel Catalysis》 was published in Organic Letters in 2020. These research results belong to Lv, Ningning; Yu, Shuling; Hong, Chao; Han, De-Man; Zhang, Yuhong. Quality Control of 3-Bromo-2-methylbenzoic acid The article mentions the following:
The oxidative cross-coupling between the α-C(sp3)-H bond of amide in DMAc and the inert ortho-C(sp2)-H bond of benzamides is achieved for the first time by nickel catalysis, with the assistance of 8-aminoquinolyl group in the presence of a silver oxidant. Notably, the selectivity of conversion can be perfectly controlled by modulating the oxidant additives, and the products from the coupling of the C(sp3)-H bond adjacent to nitrogen of amides with benzamides are approached through the use of peroxide. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Quality Control of 3-Bromo-2-methylbenzoic acid)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Quality Control of 3-Bromo-2-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary