In 2022,Li, Xinwei; Cheng, Zengrui; Liu, Jianzhong; Zhang, Ziyao; Song, Song; Jiao, Ning published an article in Chemical Science. The title of the article was 《Selective desaturation of amides: A direct approach to enamides》.Application of 7051-34-5 The author mentioned the following in the article:
C(sp3)-H bond desaturation has been an attractive strategy in organic synthesis. Enamides are important structural fragments in pharmaceuticals and versatile synthons in organic synthesis. However, the dehydrogenation of amides usually occurs on the acyl side benefitting from enolate chem. like the desaturation of ketones and esters. Herein, the authors demonstrate an Fe-assisted regioselective oxidative desaturation of amides, which provided an efficient approach to enamides, e.g., I [R1 = Me, Ph, 4-BrC6H4, cyclopropyl, etc., R2 = R3 = H, X = (CH2)n, n = 1, 2, 3, 9], and β-halogenated enamides I [R1 = n-Pr, Ph, 4-MeC6H4, etc., R2 = Br, I, R3 = H, Me, Ph]. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary