《Synthesis and cytotoxic activity of new vindoline derivatives coupled to natural and synthetic pharmacophores》 was written by Keglevich, Andras; Danyi, Leonetta; Rieder, Alexandra; Horvath, Dorottya; Szigetvari, Aron; Dekany, Miklos; Szantay, Csaba Jr.; Latif, Ahmed Dhahir; Hunyadi, Attila; Zupko, Istvan; Keglevich, Peter; Hazai, Laszlo. Product Details of 2623-87-2This research focused onvindoline derivative anticancer antiproliferative agent cytotoxicity breast cervical cancer; IC50 values; Vinca alkaloids; anticancer drugs; organic synthesis; pharmacophores; vindoline. The article conveys some information:
New Vinca alkaloid derivatives were synthesized to improve the biol. activity of the natural alkaloid vindoline. To this end, experiments were performed to link vindoline with various structural units, such as amino acids, a 1,2,3-triazole derivative, morpholine, piperazine and N-methylpiperazine. The structure of the new compounds was characterized by NMR spectroscopy and mass spectrometry (MS). Several compounds exhibited in vitro antiproliferative activity against human gynecol. cancer cell lines with IC50 values in the low micromolar concentration range. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Product Details of 2623-87-2) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Product Details of 2623-87-2
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Bromide – Wikipedia,
bromide – Wiktionary