In 2022,Horvat, Monika; Iskra, Jernej published an article in Green Chemistry. The title of the article was 《Oxidative cleavage of C-C double bond in cinnamic acids with hydrogen peroxide catalysed by vanadium(V) oxide》.Application of 586-76-5 The author mentioned the following in the article:
A cheap, green, mild and environmentally friendly method for the selective cleavage of carbon-carbon double bonds with a 30% aqueous solution of hydrogen peroxide as the oxidant and vanadium(V) oxide as the catalyst have been developed. The selectivity of the oxidative cleavage of cinnamic acid derivatives RCH=CHC(O)OR1 (R = 4-hydroxyphenyl, 2,4-dichlorophenyl, 4-hydroxy-3-methoxyphenyl, etc.; R1 = H, Et) depends on the substituents and the solvent used (DME – MeOCH2CH2OMe, TFE – 2,2,2-trifluoroethanol or MeCN). In DME, p-hydroxy derivatives were selectively converted to benzaldehyde derivatives RCHO, and in TFE, oxidative cleavage led to the formation of benzoquinone derivatives I (R2 = H, OMe), while in MeCN, cinnamic acid derivatives were selectively converted to benzoic acid derivatives RC(O)OH. Ferulic acid was quant. and selectively converted to vanillin in a 91% isolated yield on a gram scale. 3,6-Bis(4-hydroxy-3-methoxyphenyl)tetrahydro-1H,4H-furo[3,4-c]furan-1,4-dione was isolated as an intermediate, which was confirmed by in situ ATR-IR spectroscopy, while the formation of diols or epoxides was not observed The analogus styrene derivative, 4-vinylguaiacol 1e was also selectively converted to either vanillin or 2-methoxyquinone in a high yield. The green metric for the conversion of ferulic acid to vanillin by different methods was calculated and compared to this method, and showed the method has better environmental parameters.4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5) was used in this study.
4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary