In 2019,Green Chemistry included an article by Hazra, Susanta; Kushawaha, Ajay Kishor; Yadav, Deepak; Dolui, Pritam; Deb, Mayukh; Elias, Anil J.. Quality Control of 4-Bromobenzoic acid. The article was titled 《Table salt as a catalyst for the oxidation of aromatic alcohols and amines to acids and imines in aqueous medium: effectively carrying out oxidation reactions in sea water》. The information in the text is summarized as follows:
A simple, efficient, sustainable and economical method for the oxidation of alcs. and amines was developed based on chloride, a sea abundant anionic catalyst for the practical synthesis of a wide range of carboxylic acids, ketones and imines. Oxidation of aromatic alcs. was carried out using NaCl (20 mol%) as the catalyst, NaOH (50 mol%) and aqueous TBHP (4 equivalent) as the oxidant in 55-92% isolated yields. Oxidation of aromatic amines to imines was achieved by using only 20 mol% of NaCl and aqueous TBHP (4 equivalent) in 32-93% isolated yields. The chlorine species formed during the reaction as the active oxidation catalyst was identified as ClO2- for alcs. and ClO-/ClO2- for amines by control experiments This method was mostly free from chromatog. purification, which made it suitable for large-scale synthesis. The synthesis of carboxylic acids and imines scaled up to 30 g scale in good yields and was also carried out efficiently this new method using filtered sea water as the solvent and catalyst. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid)
4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary