Hanieh, Patrizia N.; Forte, Jacopo; Meo, Chiara Di; Ammendolia, Maria Grazia; Del Favero, Elena; Cantu, Laura; Rinaldi, Federica; Marianecci, Carlotta; Carafa, Maria published an article in 2021. The article was titled 《Hyaluronic acid derivative effect on niosomal coating and interaction with cellular mimetic membranes》, and you may find the article in Molecules.Electric Literature of C4H7BrO2 The information in the text is summarized as follows:
Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chem. modified to tailor its physico-chem. properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span or Tween niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chem. properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biol. membranes in future experiments The obtained coated systems showed good chem. phys. features and represent a good opportunity to carry out active targeting strategies. In addition to this study using 4-Bromobutanoic acid, there are many other studies that have used 4-Bromobutanoic acid(cas: 2623-87-2Electric Literature of C4H7BrO2) was used in this study.
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Electric Literature of C4H7BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary