In 2022,Duan, Shengzu; Zi, Yujin; Wang, Lingling; Cong, Jielun; Chen, Wen; Li, Minyan; Zhang, Hongbin; Yang, Xiaodong; Walsh, Patrick J. published an article in Chemical Science. The title of the article was 《α-Branched amines through radical coupling with 2-azaallyl anions, redox active esters and alkenes》.Related Products of 1530-32-1 The author mentioned the following in the article:
Herein, a unique cascade reaction that enables the preparation of α-branched amines I (R = Me, Ad, oxan-4-ylmethyl, etc.; R1 = H, Me, Ph; R2 = Ph; R1R2 = -(CH2)2CH(Ph)(CH2)2-; R3 = H, Me; R4 = Ph, 4-chlorophenyl, furan-3-yl, etc.) and 3-methyl-1,2,2-triphenylpentan-1-amine bearing aryl or alkyl groups at the β- or γ-positions is reported. The cascade is initiated by reduction of redox active esters II to alkyl radicals. The resulting alkyl radicals are trapped by styrene derivatives, R1C(R2)=CHR3 leading to benzylic radicals. The persistent 2-azaallyl radicals and benzylic radicals are proposed to undergo a radical-radical coupling leading to functionalized amine products I and 3-methyl-1,2,2-triphenylpentan-1-amine. Evidence is provided that the role of the nickel catalyst is to promote formation of the alkyl radical from the redox active ester and not promote the C-C bond formation. The synthetic method introduced herein tolerates a variety of imines III and redox active esters II, allowing for efficient construction of amine building blocks. The experimental part of the paper was very detailed, including the reaction process of Ethyltriphenylphosphonium bromide(cas: 1530-32-1Related Products of 1530-32-1)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Related Products of 1530-32-1
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary