SDS of cas: 2675-79-8In 2019 ,《Asymmetric synthesis of the allocolchicinoid natural product N-acetylcolchinol methyl ether (suhailamine), solid state and solution phase conformational analysis》 was published in Tetrahedron. The article was written by Davies, Stephen G.; Fletcher, Ai M.; Roberts, Paul M.; Thomson, James E.; Yeung, Angus. The article contains the following contents:
An asym. synthesis of the allocolchicinoid N-acetylcolchinol Me ether (NCME) from 3-methoxybenzaldehyde is reported. Comparison of 1H and 13C NMR spectroscopic data obtained for this sample of NCME provide further evidence for the assertion that this compound is congruous with the natural product that has been dubbed suhailamine, establishing NCME as a naturally-occurring allocolchicinoid. The single crystal X-ray diffraction structure of NCME is also reported for the first time, revealing a preference for adoption of the (7S,Ra,Z) form-i.e., describing the orientation of the biaryl axis and the amide N-CO bond as well as the configuration of the stereogenic center-in the solid state. A preference for the same form in DMSO-d6 solution is revealed upon anal. by a range of NMR spectroscopic techniques, while an interconverting 69:24:7 mixture of the (7S,Ra,Z), (7S,Sa,Z) and (7S,Ra,E) forms is observed in CDCl3. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8SDS of cas: 2675-79-8)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.SDS of cas: 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary