Cruz, Cole L.; Montgomery, John published their research in Chemical Science in 2021. The article was titled 《Nickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes》.Application In Synthesis of Ethyl 3-bromopropanoate The article contains the following contents:
A mild, convenient coupling of aliphatic aldehydes e.g., BnCH2CHO and unactivated alkyl bromides e.g., Br(CH2)3C(O)OEt has been developed. The catalytic system features the use of a common Ni(II) precatalyst and a readily available bioxazoline ligand and affords silyl-protected secondary alcs. e.g., BnCH2CH(OTES)(CH2)3C(O)OEt. The reaction is operationally simple, utilizes Mn as a stoichiometric reductant, and tolerates a wide range of functional groups. The use of 1,5-hexadiene as an additive is an important reaction parameter that provides significant benefits in yield optimizations. Initial mechanistic experiments support a mechanism featuring an alpha-silyloxy Ni species that undergoes formal oxidative addition to the alkyl bromide via a reductive cross-coupling pathway. In addition to this study using Ethyl 3-bromopropanoate, there are many other studies that have used Ethyl 3-bromopropanoate(cas: 539-74-2Application In Synthesis of Ethyl 3-bromopropanoate) was used in this study.
Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Application In Synthesis of Ethyl 3-bromopropanoate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary