The author of 《End-Chain Fluorescent Highly Branched Poly(L-lactide)s: Synthesis, Architecture-Dependence, and Fluorescent Visible Paclitaxel-Loaded Microspheres》 were Bian, Yufei; Leng, Xuefei; Wei, Zhiyong; Wang, Zefeng; Tu, Zhu; Wang, Yanshai; Li, Yang. And the article was published in Biomacromolecules in 2019. COA of Formula: C6H11BrO2 The author mentioned the following in the article:
A facile method in combination of “”grafting from”” and “”end-functionalization”” was developed for the synthesis of fluorescent highly branched poly(L-lactide)s (PLLA-COU) via ring opening polymerization (ROP) and esterification end-capping. These resulting PLLA-COU with four kinds of architectures, including linear, star, linear-comb, and star-comb structures, were subjected to characterization and application as fluorescent visible paclitaxel-loaded microspheres. The mutual effects of architecture and end-groups on thermal and fluorescence properties, enzymic degradation, and drug release behaviors were focused. Contrast to linear and star PLLA-COU, two comb-shaped analogs demonstrated higher fluorescence quantum yield, faster drug release, and lower enzymic degradation rate. All the fluorescent microspheres could maintain fluorescence traceability. The fluorescent PLLA-COU displayed negligible toxicity and good biocompatibility. This work highlights that the fluorescent highly branched poly(L-lactide)s are properties-tailored and used as fluorescent visible drug delivery systems (DDS) for potential theranostic applications. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5COA of Formula: C6H11BrO2) was used in this study.
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.COA of Formula: C6H11BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary