《Transition-Metal-Free Site-Selective γ-C(sp2)-H Monoiodination of Arenes Directed by an Aliphatic Keto Group》 was written by Bian, Hong-Li; Tang, Shi-Zhong; Chen, Meng-En; Zhang, Xiao-Ming; Lv, Jian-Wei; Chen, Xiao-Wei; Qi, Feng-Ming; Chen, Shi-Wu; Zhang, Fu-Min. Category: bromides-buliding-blocks And the article was included in Organic Letters in 2020. The article conveys some information:
A general γ-C(sp2)-H iodination method directed by an aliphatic keto group has been developed under transition-metal-free conditions for the first time, generating iodoarenes I (X = (CH2)n; n = 0, 1, 2; R = H, 5-bromo, 3,4,5-trimethoxy, etc.; R1 = H, 2-iodophenyl; R2 = H; R1R2 = -CH=CH-CH=CH-), R3C(O)CH(R4)R5 (R3 = Me, Ph, 4-chlorophenyl, etc.; R4 = H, ethyl; R5 = 2-iodophenyl, 2-iodo-4,5-dimethoxyphenyl, 5-chloro-2-iodophenyl, etc.) and 7-(2-iodophenyl)-1,4-dioxaspiro[4.5]decan-8-one in good to excellent yields with excellent site selectivity. This protocol features a wide range of aryl-substituted ketones II, R3C(O)CH(R4)R6 (R6 = Ph, 4-methylphenyl, 4-fluorophenyl, etc.) and 7-phenyl-1,4-dioxaspiro[4.5]decan-8-one, short reaction times, mild reaction conditions, and scalable synthetic procedures. A possible reaction mechanism was also proposed based on several control experiments In the experiment, the researchers used many compounds, for example, 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Category: bromides-buliding-blocks)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Category: bromides-buliding-blocks1-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary