In 2022,Zheng, Chenggong; Yan, Fangpei; Liu, Yaomei; Chen, Rui; Zheng, Kaiting; Xiao, Hua; Li, Xiao-Xuan; Feng, Yi-Si; Fan, Shilu published an article in Organic Letters. The title of the article was 《Regioselective Alkylpolyfluoroarylation of Styrenes by Copper-Catalyzed C(sp3)-H and C(sp2)-H Double Activation》.Recommanded Product: 2635-13-4 The author mentioned the following in the article:
A novel dehydrogenative dicarbofunctionalization of vinyl arenes ArCH=CHR (Ar = Ph, thiophen-2-yl, 2H-1,3-benzodioxol-5-yl, etc.; R = H, Me) with polyfluoroarenes I (R1 = F, OMe, Ph, etc.) and inactivated alkanes such as cyclohexane, cyclopentane, cycloheptane, etc. enabled by copper catalysis has been accomplished under mild conditions. This transformation provides a regioselective route to highly functionalized polyfluoroaryl compds II (R2 = cyclopentyl, cyclohexyl, cycloheptyl, etc.) that occur as structural scaffolds in a variety of pharmaceuticals and materials. Preliminary mechanistic studies indicate that the carbon-based radical and copper intermediate are involved in the reaction, and the reaction pathway is dominated by the bond dissociation energy (BDE) of C(sp3)-H bonds. In the part of experimental materials, we found many familiar compounds, such as 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Recommanded Product: 2635-13-4)
Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Recommanded Product: 2635-13-4
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary