In 2022,Zhang, Jian-Xin; Shu, Wei published an article in Organic Letters. The title of the article was 《Ni-Catalyzed Reductive 1,2-Cross-Dialkylation of Unactivated Alkenes with Two Alkyl Bromides》.Category: bromides-buliding-blocks The author mentioned the following in the article:
Herein, a Ni-catalyzed reductive 1,2-dialkylation of unactivated aliphatic alkenes had been developed using two different alkyl bromides to gave (cyanoethyl)-alkyl-aryl-propanamides R1CH2CHR2CH2C(O)NHAr [R1 = cyanomethyl, H2CCO2Et, (2-oxotetrahydrofuran-3-yl); R2 = Et, n-Pr, 3-phenylpropyl, etc.; Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.]. The reaction proceeded smoothly under mild conditions to install two Csp3-Csp3 bonds onto directed aliphatic alkenes, demonstrating excellent chemo- and regioselectivity with good functional group tolerance. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary