Zhan, Yi-Zhou; Xiao, Nan; Shu, Wei published their research in Nature Communications in 2021. The article was titled 《Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group》.Synthetic Route of C4H7Br The article contains the following contents:
The nickel-catalyzed intermol. cross-dialkylation of alkynes devoid of directing or activating groups afforded multiple aliphatic substituted alkenes in a syn-selective fashion at room temp was reported. The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enabled the syn-cross-dialkylation of alkynes at room temperature This reductive protocol enabled the sequential installation of two different alkyl substituents onto alkynes in a regio- and stereo-selective manner, circumvented the tedious preformation of sensitive organometallic reagents. The synthetic utility of this protocol was demonstrated by efficient synthesis of multi-substituted unfunctionalized alkenes and diverse transformations of the product. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br) was used in this study.
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary