Wu, Sisi; Shi, Weijia; Zou, Gang published an article in 2021. The article was titled 《Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides》, and you may find the article in New Journal of Chemistry.SDS of cas: 2969-81-5 The information in the text is summarized as follows:
Liquid-assisted grinding was successfully applied to eliminate the requirements of chem. activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mech. ones, e.g. the rotational speed of mill, the filling degree of jar and ball size, was found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mech. parameters led to an optimal condition under which a variety of n-alky aromatics with various functional groups was readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling was demonstrated in the gram-scale synthesis of 6-methoxytetralone. The experimental process involved the reaction of Ethyl 4-bromobutyrate(cas: 2969-81-5SDS of cas: 2969-81-5)
Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact.SDS of cas: 2969-81-5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary