Uji, Hirotaka; Watabe, Naoki; Komi, Tatsuya; Sakaguchi, Tomoki; Akamatsu, Ryo; Mihara, Kenta; Kimura, Shunsaku published an article in 2022. The article was titled 《Downsizing to 25-nm Reverse Polymeric Micelle Composed of AB3-type Polydepsipeptide with Comprising siRNA》, and you may find the article in Chemistry Letters.Application of 5437-45-6 The information in the text is summarized as follows:
Amphiphilic block polydepsipeptides of AB-type and AB3-type (hydrophilic A block: poly(sarcosine), hydrophobic B block: poly(l-lactic acid)) were prepared, and the N-terminals were arranged by guanidium or guanidino-peptide nucleic acid for loading siRNA in a reverse polymeric micelle. The amphiphilic polymers were successfully dispersed and assembled into reverse micelles in triglyceride or diisopropyl adipate. With loading siRNA into the core of the polymeric micelles, the micelle size was reduced down to a diameter of 25 nm in the case of the guanidino-peptide nucleic acid used as the capturing site. This small-size reverse micelle may be available for a transdermal drug delivery system (DDS) for siRNA. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Application of 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary