In 2011,Trabanco, Andres A.; Duvey, Guillaume; Cid, Jose Maria; Macdonald, Gregor J.; Cluzeau, Philippe; Nhem, Vanthea; Furnari, Rocco; Behaj, Nadia; Poulain, Geraldine; Finn, Terry; Poli, Sonia; Lavreysen, Hilde; Raux, Alexandre; Thollon, Yves; Poirier, Nicolas; D’Addona, David; Andres, Jose Ignacio; Lutjens, Robert; Le Poul, Emmanuel; Imogai, Hassan; Rocher, Jean-Philippe published 《New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones》.MedChemComm published the findings.Electric Literature of C8H7BrO2 The information in the text is summarized as follows:
A series of N-propyl-5-substituted isoquinolones was identified as pos. allosteric modulators (PAM) of metabotropic glutamate receptor 2 (mGluR2) via high-throughput screening (HTS). The subsequent synthesis and preliminary SAR exploration that led to the identification of compound 20 are described. After reading the article, we found that the author used 3-Bromo-2-methylbenzoic acid(cas: 76006-33-2Electric Literature of C8H7BrO2)
3-Bromo-2-methylbenzoic acid(cas: 76006-33-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals.Electric Literature of C8H7BrO2 Organobromine compounds have fallen under increased scrutiny for their environmental impact.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary