《Development of an efficient and sustainable synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl)acetic acid under continuous-flow conditions》 was written by Tortoioli, Simone; Friedli, Astrid; Prud’homme, Alice; Richard-Bildstein, Sylvia; Kohler, Philipp; Abele, Stefan; Vile, Gianvito. Related Products of 5437-45-6This research focused ontriazole preparation green chem continuous flow. The article conveys some information:
A novel, metal-free process for the challenging synthesis of 2-(3-methyl-1H-1,2,4-triazol-1-yl)acetic acid is reported, which features an efficient construction of the triazole ring under flow conditions. This continuous, one-pot method is atom economical, highly selective and environmentally benign, due to the avoidance of chromatog. and isolation steps. Compared to the earlier batch routes, higher yields were achieved in a flow reactor. In addition, a highly-energetic intermediate could be controlled and handled in a safe manner. To generalize the established route, several triazoles I (R = CH2CO2Et, CH2CO2CH2C6H5, 4-FC6H4, CH2C6H5, 4-OCH3C6H4CH2, cyclohexyl; R1 = H, 5-bromopyridin-3-yl) were prepared under the described conditions, confirming that the methodol. could find useful applications for the rapid and sustainable construction of differentially-functionalized 1,2,4-triazoles.Benzyl 2-bromoacetate(cas: 5437-45-6Related Products of 5437-45-6) was used in this study.
Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Related Products of 5437-45-6
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary