《Alkyl vs. aryl modifications: a comparative study on modular modifications of triphenylphosphonium mitochondrial vectors》 was written by Ong, How Chee; Coimbra, Joao T. S.; Kwek, Germain; Ramos, Maria J.; Xing, Bengang; Fernandes, Pedro A.; Garcia, Felipe. Application In Synthesis of Ethyltriphenylphosphonium bromideThis research focused ontriphenylphosphonium mitochondrial vector alkyl aryl modification lipophilicity. The article conveys some information:
Triphenylphosphonium (TPP+) moieties are commonly conjugated to drug mols. to confer mitochondrial selectivity due to their pos. charge and high lipophilicity. Although optimization of lipophilicity can be achieved by modifying the length of the alkyl linkers between the TPP+ moiety and the drug mol., it is not always possible. While methylation of the TPP+ moiety is a viable alternative to increase lipophilicity and mitochondrial accumulation, there are no studies comparing these two sep. modular approaches. Thus, we have systematically designed, synthesized and tested a range of TPP+ mols. with varying alkyl chain lengths and degree of aryl methylation to compare the two modular methodologies for modulating lipophilicity. The ability of aryl/alkyl modified TPP+ to deliver cargo to the mitochondria was also evaluated by confocal imaging with a TPP+-conjugated fluorescein-based fluorophore. Furthermore, we have employed mol. dynamics simulations to understand the translocation of these mols. through biol. membrane model systems. These results provide further insights into the thermodn. of this process and the effect of alkyl and aryl modular modifications. In the part of experimental materials, we found many familiar compounds, such as Ethyltriphenylphosphonium bromide(cas: 1530-32-1Application In Synthesis of Ethyltriphenylphosphonium bromide)
Ethyltriphenylphosphonium bromide(cas: 1530-32-1) is a phase transfer catalyst, used to accelerate the cure of phenolic-based epoxy resins, certain fluoroelastomer resins and thermosetting powder coatings. CatOnium ETPB is also used as catalysts in the synthesis of certain organic compounds.Application In Synthesis of Ethyltriphenylphosphonium bromide
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary