In 2019,Organic Letters included an article by Munoz, Socrates B.; Dang, Huong; Ispizua-Rodriguez, Xanath; Mathew, Thomas; Prakash, G. K. Surya. Formula: C7H5BrO2. The article was titled 《Direct Access to Acyl Fluorides from Carboxylic Acids Using a Phosphine/Fluoride Deoxyfluorination Reagent System》. The information in the text is summarized as follows:
A fast and simple method for deoxyfluorination of carboxylic acids is presented. The protocol employs commodity chems. (PPh3, NBS, fluoride), affording products in excellent yields under mild conditions. Acyloxyphosphonium ion, the key reaction intermediate, was identified by NMR spectroscopic methods. Bronsted acidic conditions are essential for efficient C-F bond formation. The protocol displays scalability, high functional group tolerance, chemoselectivity, and easy purification of products. Deoxyfluorination of active pharmaceutical ingredients was established. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary