In 2022,Li, Xing-Ren; Hu, Kun; Yan, Bing-Chao; Li, Xiao-Nian; Sun, Han-Dong; Liu, Yang; Puno, Pema-Tenzin published an article in Bioorganic Chemistry. The title of the article was 《Scopariusicides D-M, ent-clerodane-based isomeric meroditerpenoids with a cyclobutane-fused γ/δ-lactone core from Isodon scoparius》.Formula: C7H5BrO2 The author mentioned the following in the article:
Scopariusicides D-M (1-10), ten new ent-clerodane-based meroditerpenoids with a cyclobutane-fused γ/δ-lactone core, were isolated from Isodon scoparius. Their structures were determined by comprehensive anal. of spectroscopic data, single-crystal X-ray diffraction, chem. transformation, and TDDFT ECD calculation A plausible biosynthetic pathway of 1-10 was proposed in which the asym. cyclobutane ring was formed via a crossed “”head-to-tail”” intermol. [2 + 2] cycloaddition in anti/syn facial approaches between an ent-clerodane lactone and a cis-4-hydroxycinnamic acid. Bioactivity evaluation manifested that 5 exhibited significant neuroprotective effect against corticosterone-induced injury in PC12 cells, while 6 and 7 exhibited moderate immunosuppressive activity against human T cell proliferation stimulated by anti-CD3/anti-CD28 mAb. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)
4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary