《Catalytic enantioselective synthesis of carbocyclic and heterocyclic spiranes via a decarboxylative aldol cyclization》 was published in Chemical Science in 2020. These research results belong to Inanaga, Kazato; Wollenburg, Marco; Bachman, Shoshana; Hafeman, Nicholas J.; Stoltz, Brian M.. Related Products of 14660-52-7 The article mentions the following:
The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters via an interrupted asym. allylic alkylation is disclosed. Substrates possessing pendant aldehydes undergo decarboxylative enolate formation in the presence of a chiral Pd catalyst and subsequently participate in an enantio- and diastereoselective, intramol. aldol reaction to furnish spirocyclic β-hydroxy ketones which may be oxidized to the corresponding enantioenriched diketospiranes. Addnl., this chem. has been extended to α-allylcarboxy lactam substrates leading to a formal synthesis of the natural product (-)-isonitramine. The experimental process involved the reaction of Ethyl 5-bromovalerate(cas: 14660-52-7Related Products of 14660-52-7)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Related Products of 14660-52-7
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary