Hermann, Theresa; Hochegger, Patrick; Dolensky, Johanna; Seebacher, Werner; Saf, Robert; Kaiser, Marcel; Maeser, Pascal; Weis, Robert published their research in Pharmaceuticals in 2021. The article was titled 《New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities》.Computed Properties of C9H9BrO2 The article contains the following contents:
An N-acylated furazan-3-amine of a Medicines for Malaria Venture (MMV) project has shown activity against different strains of Plasmodium falciparum. Seventeen new derivatives were prepared and tested in vitro for their activities against blood stages of two strains of Plasmodium falciparum. Several structure-activity relationships were revealed. The activity strongly depended on the nature of the acyl moiety. Only benzamides showed promising activity. The substitution pattern of their Ph ring affected the activity and the cytotoxicity of compounds In addition, physicochem. parameters were calculated (log P, log D, ligand efficiency) or determined exptl. (permeability) via a PAMPA. The N-(4-(3,4-diethoxyphenyl)-1,2,5-oxadiazol-3-yl)-3-(trifluoromethyl)benzamide possessed good physicochem. properties and showed high antiplasmodial activity against a chloroquine-sensitive strain (IC50(NF54) = 0.019 μM) and even higher antiplasmodial activity against a multiresistant strain (IC50(K1) = 0.007 μM). Compared to the MMV compound, the permeability and the activity against the multiresistant strain were improved. The results came from multiple reactions, including the reaction of Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8Computed Properties of C9H9BrO2)
Methyl 3-(bromomethyl)benzoate(cas: 1129-28-8) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Computed Properties of C9H9BrO2 The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary