In 2019,Organic Letters included an article by Elek, Gabor Zoltan; Koppel, Kaur; Zubrytski, Dzmitry M.; Konrad, Nele; Jarving, Ivar; Lopp, Margus; Kananovich, Dzmitry G.. Computed Properties of C7H13BrO2. The article was titled 《Divergent access to histone deacetylase inhibitory cyclopeptides via a late-stage cyclopropane ring cleavage strategy. Short synthesis of chlamydocin》. The information in the text is summarized as follows:
A unified step-economical strategy for accessing histone deacetylase inhibitory peptides is proposed, based on the late-stage installation of multiple zinc-binding functionalities via the cleavage of the strained cyclopropane ring in the common pluripotent cyclopropanol precursor. The efficacy of the proposed diversity-oriented approach has been validated by short stereoselective synthesis of natural product chlamydocin, containing a challenging-to-install fragment of (2S,9S)-2-amino-8-oxo-9,10-epoxydecanoic acid (Aoe) and a range of its analogs, derivatives of 2-amino-8-oxodecanoic and 2-aminosuberic acids. After reading the article, we found that the author used Ethyl 5-bromovalerate(cas: 14660-52-7Computed Properties of C7H13BrO2)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Computed Properties of C7H13BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary