Duan, Jingxiang; Xiong, Zongli; Zhou, Yuqiao; Yao, Weijun; Li, Xiaoyi; Zhang, Min; Wang, Zhen published their research in Organic Letters in 2021. The article was titled 《Access to Chiral Chromenones through Organocatalyzed Mannich/Annulation Sequence》.Recommanded Product: Benzyl 2-bromoacetate The article contains the following contents:
An efficient and practical method to access chiral chromenones I (R1 = H, 5-OBn, 6-Cl, 7-OMe, etc.; R2 = H, Me, n-pentyl, 2-phenylethenyl, etc.; R3 = Ph, TMS, cyclohexyl, etc.), II bearing one α-amino stereogenic center in the β position of the carbonyl group was reported. The quinine-derived squaramide could efficiently promote Mannich/cycloketalization/dehydration tandem reactions between 1-(2-hydroxyaryl)-1,3-diketones 2-OH-R4C6H3C(O)CH2C(O)R2 (R4 = H, 5-Cl, 4-OMe, 4-OBn, etc.) and functionalized imines R3CCCH(NHBoc)OEt/R5N(OBoc)CH2COOBn (R5 = Cbz, Boc) generated in situ, providing a wide range of chiral chromenones with propargylamine I or α-amino ester moieties II with good results (54 examples, up to 98% ee). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: Benzyl 2-bromoacetate)
Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Recommanded Product: Benzyl 2-bromoacetate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary