The author of 《Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O2 as an oxidant》 were Dong, Jianyang; Lyu, Xueli; Wang, Zhen; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin. And the article was published in Chemical Science in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:
A protocol for direct visible-light-mediated Minisci C-H alkylation of heteroarenes, e.g., lepidine with unactivated alkyl halides RX (R = Pr, benzyl, 2-phenoxyethyl, adamantan-1-yl, etc.; X = Br, I) using mol. oxygen as an oxidant at room temp was reported. This mild protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope. Notably, functionalization of heterocyclic compounds e.g., I with unactivated alkyl halides proceeds smoothly under the standard conditions. The robustness of this protocol is further demonstrated by the late-stage functionalization of complex nitrogen-containing natural products and drugs e.g., II. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Category: bromides-buliding-blocks)
(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary