The author of 《Interchain doubly-bridged α-helical peptides for the development of protein binders》 were Chen, Yaqi; Liang, Jingjing; Li, Tao; Lin, Ping; Zhao, Yibing; Wu, Chuanliu. And the article was published in Chinese Chemical Letters in 2019. Computed Properties of C8H8Br2 The author mentioned the following in the article:
Constrained peptide scaffolds that are tolerant to extensive sequence manipulation and amenable to bioactive peptide design are of great value to the development of novel protein binders and peptide therapeutics. The authors reported strategies for the design and synthesis of a kind of novel interchain doubly-bridged α-helical peptides, involving mutual stabilization of two peptide α-helixes linked by two interchain bisthioether crosslinkers. By taking a MDM2-binding peptide with an α-helical tendency as a model, α-helical dimers with significantly improved structural and proteolytic stability and nanomolar binding affinity to the target protein can be obtained. By modulating the surface charges on the dimeric peptides, the authors also obtained a dimeric peptide with enhanced cell-penetrating capability, which can efficiently penetrate into cancer cells and inhibit the intracellular MDM2-p53 interactions to promote cell apoptosis. Considering that many proteins take a surface α-helical segment as the binding motif to mediate their interactions with other proteins, the authors believe that the authors’ interchain doubly-bridged α-helical peptides would provide a promising scaffold for the development of novel high-affinity protein binders.1,4-Bis(bromomethyl)benzene(cas: 623-24-5Computed Properties of C8H8Br2) was used in this study.
1,4-Bis(bromomethyl)benzene(cas: 623-24-5) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Computed Properties of C8H8Br2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary