Chakraborty, Mithun; Mahesh, Gaddam; Nakel, Omkar R.; Chavda, Gautamee; Anusha, Susarla; Sudhakar, Gangarajula published an article in 2021. The article was titled 《A Facile Approach to Access Multi-Substituted Indenes via Nazarov Cyclization of Aryl, Vinyl and Alkyl/Aryl Carbinols》, and you may find the article in ChemistrySelect.Related Products of 2675-79-8 The information in the text is summarized as follows:
A divergent approach to highly substituted functionalized indenes I [R1 = H, Me, Ph, etc.; R2 = H, Me; R3 = Me, Et, Ph; R4 = 6-OMe, 5,7-(OMe)2, 5,6,7-(OMe)3, etc.; R5 = CH2-CO2Et, 4-MeOC6H4, 2-FC6H4, etc.] was developed. The two-step reaction involved nucleophilic addition reaction of aryl vinyl ketone, an ideal intermediate with aryl or alkyl nucleophilic reagent, followed by electrocyclic reaction (Nazarov cyclization) in the presence of Lewis acid catalyst afforded indene derivatives I in good to excellent yield. After reading the article, we found that the author used 1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8Related Products of 2675-79-8)
1-Bromo-3,4,5-trimethoxybenzene(cas: 2675-79-8) is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.Related Products of 2675-79-81-Bromo-3,4,5-trimethoxybenzene can be used to synthesize analogs of HA14-1, which shows promising anticancer properties.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary