Yu, Xi-Hui; Cai, Xiong-Jie; Hong, Xiao-Qiao; Tam, Kin Yip; Zhang, Kun; Chen, Wen-Hua published an article in 2019, the title of the article was Synthesis and biological evaluation of aza-crown ether-squaramide conjugates as anion/cation symporters.Electric Literature of 574-98-1 And the article contains the following content:
Anion/cation symport across cellular membranes may lead to cell apoptosis and be developed as a strategy for new anticancer drug discovery. Four aza-crown ether-squaramide conjugates were synthesized and characterized. Their anion recognition, anion/cation symport, cytotoxicity and probable mechanism of action were investigated in details. These conjugates are able to form ion-pairing complexes with chloride anions and facilitate the transmembrane transport of anions via an anion/cation symport process. They can disrupt the cellular homeostasis of chloride anions and sodium cations and induce the basification of acidic organelles in live cells. These conjugates exhibit moderate cytotoxicity toward the tested cancer cells and trigger cell apoptosis by mediating the influx of chloride anions and sodium cations into live cells. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Electric Literature of 574-98-1
The Article related to aza ether squaramide anion cation cervical cancer antitumor agent, anion/cation symporter, anionophoric activity, antiproliferative activity, aza-crown ether, squaramide, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.Electric Literature of 574-98-1
Referemce:
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