On September 15, 2011, Yeung, Kap-Sun; Parcella, Kyle E.; Bender, John A.; Beno, Brett R.; Grant-Young, Katharine A.; Han, Ying; Hewawasam, Piyasena; Kadow, John F.; Nickel, Andrew published a patent.Quality Control of 5-Bromo-2-methoxy-4-methylbenzoic acid The title of the patent was Preparation of benzofurancarboxamide derivatives and their preparation and use for the treatment of hepatitis C. And the patent contained the following:
The invention relates to benzofurancarboxamide derivatives of formula I, which are useful for treatment of hepatitis C. Compounds of formula I wherein R1 is NR5R6, alkoxy, Ph, etc.; R2 is H, halo, NO2, NH2, Ph and NR5R6; R3 is CN, alkoxycarbonyl, (cycloalkyl)oxycarbonyl, etc.; R4 is substituted Ph; R5 is H, alkyl and alkylsulfonyl; R6 is H, alkyl, hydroxyalkyl, alkoxyalkyl and alkylsulfonyl; R20 and R21 are independently H, halo, alkyl and alkoxy; and pharmaceutically acceptable salts thereof, are disclosed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their activity against HCV. From the assay, it was determined that compound II exhibited IC50 and EC50 values in the range 0.002 – 0.25 μM, resp. The experimental process involved the reaction of 5-Bromo-2-methoxy-4-methylbenzoic acid(cas: 90326-61-7).Quality Control of 5-Bromo-2-methoxy-4-methylbenzoic acid
The Article related to benzofurancarboxamide preparation treatment hepatitis c, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Quality Control of 5-Bromo-2-methoxy-4-methylbenzoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary