On October 21, 2021, Xiong, Yuan; Donovan, Katherine A.; Eleuteri, Nicholas A.; Kirmani, Nadia; Yue, Hong; Razov, Anthony; Krupnick, Noah M.; Nowak, Radoslaw P.; Fischer, Eric S. published an article.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Chemo-proteomics exploration of HDAC degradability by small molecule degraders. And the article contained the following:
Targeted protein degradation refers to the use of small mols. that recruit a ubiquitin ligase to a target protein for ubiquitination and subsequent proteasome-dependent degradation While degraders have been developed for many targets, key questions regarding degrader development and the consequences of acute pharmacol. degradation remain, specifically for targets that exist in obligate multi-protein complexes. Here, we synthesize a pan-histone deacetylase (HDAC) degrader library for the chemo-proteomic exploration of acute degradation of a key class of chromatin-modifying enzymes. Using chemo-proteomics, we not only map the degradability of the zinc-dependent HDAC family identifying leads for targeting HDACs 1-8 and 10 but also explore important aspects of degrading epigenetic enzymes. We discover cell line-driven target specificity and that HDAC degradation often results in collateral loss of HDAC-containing repressive complexes. These findings potentially offer a new mechanism toward controlling chromatin structure, and our resource will facilitate accelerated degrader design and development for HDACs. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione
The Article related to hdac degradability small mol degrader chemoproteomics exploration, e3 ligase, hdac, imid, protac, collateral degradation, degrader, targeted degradation, ubiquitin, Placeholder for records without volume info and other aspects.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione
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