《Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids》 was published in Journal of Medicinal Chemistry in 2020. These research results belong to Wu, Jianbo; Wang, Xiaofang; Chiu, Francis C. K.; Haberli, Cecile; Shackleford, David M.; Ryan, Eileen; Kamaraj, Sriraghavan; Bulbule, Vivek J.; Wallick, Alexander I.; Dong, Yuxiang; White, Karen L.; Davis, Paul H.; Charman, Susan A.; Keiser, Jennifer; Vennerstrom, Jonathan L.. Reference of Ethyl 5-bromovalerate The article mentions the following:
Semisynthetic artemisinins and other bioactive peroxides are best known for their powerful antimalarial activities, and they also show substantial activity against schistosomes-another Hb-degrading pathogen. Building on this discovery, we now describe the initial structure-activity relationship (SAR) of antischistosomal ozonide carboxylic acids OZ418 (2) and OZ165 (3). Irresp. of lipophilicity, these ozonide weak acids have relatively low aqueous solubilities and high protein binding values. Ozonides with para-substituted carboxymethoxy and N-benzylglycine substituents had high antischistosomal efficacies. It was possible to increase solubility, decrease protein binding, and maintain the high antischistosomal activity in mice infected with juvenile and adult Schistosoma mansoni by incorporating a weak base functional group in these compounds In some cases, adding polar functional groups and heteroatoms to the spiroadamantane substructure increased the solubility and metabolic stability, but in all cases decreased the antischistosomal activity. In the part of experimental materials, we found many familiar compounds, such as Ethyl 5-bromovalerate(cas: 14660-52-7Reference of Ethyl 5-bromovalerate)
Ethyl 5-bromovalerate(cas: 14660-52-7) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Reference of Ethyl 5-bromovalerate
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary